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apalutamide will reduce the level or influence of triazolam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Keep away from or Use Alternate Drug. Coadministration of apalutamide, a solid CYP3A4 inducer, with medicines that happen to be CYP3A4 substrates may lead to lower exposure to these medicines.For anyone who is allergic to this drug;